Nanoparticle‐Mediated Intracellular Protection of Natural Killer Cells Avoids Cryoinjury and Retains Potent Antitumor Functions
نویسندگان
چکیده
منابع مشابه
Antitumor Responses of Invariant Natural Killer T Cells
Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function. These studies have highlighted the unique requirements for the activation of these lymphocytes and the functional responses that distinguish these cells from other effector...
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Natural killer (NK) cells serve as important effectors for antitumor immunity, and CD56+CD45+ NK cells can be routinely derived from human embryonic stem cells (hESCs). However, little is know about the ability of hESC-derived NK cells to mediate an effective in vivo antitumor response. Using bioluminescent imaging, we now demonstrate that H9 line hESC-derived NK cells mediate effective clearan...
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Although there are many Chinese and Japanese reports of the use of immuno-stimulants in treating cancer, the Western medical profession is generally unfamiliar with them. This is partly due to the Western preference for rather more aggressive Western techniques and partly due to a lack of awareness. When I recently asked a well-known UK cancer expert his views on immuno-stimulants, he said he w...
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The use of interleukin-18 (IL-18) together with IL-12 induced high levels of IFN-gamma in tumor-bearing mice and regression of liver tumors that was abolished in IFN-gamma((-/-)) mice. Natural killer (NK) and NKT cells were the major producers of IFN-gamma in the livers of mice treated with IL-18 and/or IL-12. Liver NK cells were significantly increased by treatment with IL-18/IL-12, whereas th...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2020
ISSN: 2198-3844,2198-3844
DOI: 10.1002/advs.201902938